Endocrine Abstracts

In cardiovascular-renal (CVR) pathology, the renin (REN)-angiotensin (A2) system (RAS) is central as key regulator of blood pressure BP (major CVR risk factor), and it is widely targeted by therapeutical agents. CVR regulations are utterly complex: realistic and integrated models are needed. However RAS is absent or crude in existing models: in the most integrative one (Guyton’s model GM), it is restricted to a simple factor acting on resistances and aldosterone: key elem...